The effect of powder surface chemistry on high shear wet granulation performance for co-agglomerating untreated and silanized D-mannitol powder is discussed. The wetting performance of polyvinylpyrrolidone (PVP) binder solutions was quantified using experimentally determined thermodynamic spreading coefficients, using the surface energy heterogeneity distributions, obtained via inverse gas chromatography (iGC) measurements, for the mannitol powders. Increases in binder wettability of the formulations correlated with increases in both granule size and granule compressive elastic moduli, which are attributed to an increase in interparticle contacts. In conclusion, powder surface chemistry plays a crucial role in final granule properties, even in highly agitated processes such as high shear granulation. The comprehensive characterization of powder surface properties is necessary to facilitate the manufacture of granules with controllable critical attributes.
Date: Wednesday, 4 June 2020
Duration: 25 mins including Q&A
Determining the Tg for Polymers and Polymeric Surface Coatings
using Inverse Gas Chromatography (iGC)
Inverse Gas Chromatography (iGC) can be used to determine the surface properties of many materials. In some cases, as well as surface adsorption, there is also bulk sorption of the iGC probe molecules, allowing bulk materials properties to also be determined.
The webinar will discus the use of iGC technique for:
Determining the Tg of polymeric materials and
Tg of polymer coatings when applied to highly crystalline fibres, such as fibre sizing and coatings