Determination of the surface potential and isoelectric point of ion-exchange membranes with a zeta potential analyzer

courtesy of DataPhysics

ZPA 20 Award XSIon-exchange membranes are widely used in numerous applications, such as water treatment, chemistry, electrolysis, sensorics and other fields. A good ion transfer selectivity of the ion-exchange membrane is highly important for all of these applications. The charge structure and composition of ion-exchange membranes has a strong influence on the mobility of different ions or molecules and thus governs the selectivity of ion transport processes through the membrane.[1] Therefore, it is of great importance to have a good technique to characterise the charged surface functionalities of ion-exchange membranes. A powerful technique to evaluate charged surface functionalities is the measurement of the zeta potential, that is, the electric potential of solid surfaces in contact with an electrolyte solution. With this information it is possible to better understand the dissociation state of functional groups on the surface, and conclude the electrostatic interactions that will occur with other materials such as charged particles. The new Zeta Potential Analyzer ZPA 20 from DataPhysics Instruments (Fig. 1) measures the zeta potential of fibres, powders and plate shaped surfaces by means of a novel bidirectional oscillating streaming potential or streaming current technique. In this application note, we study the functional groups of different ion-exchange membrane surfaces with the ZPA 20.

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Surface Measurment Systems launches the Sorption Store

store1.jpg

Surface Measurement Systems recently announced the launch of their new online store. Your one-stop shop for consumables and accessories for DVS,IGC, and Breakthrough Analysis instruments. Enjoy instant payment and fast delivery, so your team can focus on top-notch results!

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Pamas - liquid particle counters for industry

by Albrecht Truter

Founded in 1992, PAMAS develops, manufactures, distributes and services laser particle counters to measure particulate contamination in liquids. They offer a range of particle counters from online particle counters like the S50, portable counters like the S40 / S40Go  and the flagship benchtop particle size analyser the SBSS.

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Why is 50% the Limit for Particle Counting Efficiency Sizing Thresholds?

courtesy of Particle Measuring Systems

particleParticle counting efficiency is crucial in particle measurement, especially when using optical particle counters. This term denotes the likelihood of precisely detecting and enumerating particles within a specified size spectrum. In this context, the term “particle counting efficiency” represents the ability of the particle counter to quantify particles of a given size accurately. It measures the instrument’s performance, indicating how effectively it can detect and count particles of various sizes.

The significance of particle counting efficiency lies in its direct impact on the reliability and accuracy of particle measurement. For instance, in applications such as air quality monitoring, pharmaceutical manufacturing, or research in aerosol science, the precision in measuring particle size and concentration is paramount. A higher counting efficiency means the counter is more effective in detecting and counting the particles within its designated size range, leading to more accurate and reliable data.

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DataPhysics Instruments introduces the new, Portable Contact Angle Goniometer PCA 200 for precise determination of the Surface Energy

courtesy of DataPhysics

Studying Moisture Induced Transformations and Degradation of Pharmaceutical Ingredients Using Raman Spectroscopy Combined with Dynamic Vapor Sorption

courtesy of Surface Measurement Systems

DVS DiscoveryThis study investigates the chemical degradation and dehydration behaviours of pharmaceutical compounds, acetylsalicylic acid (ASA) and citric acid monohydrate, used in drug formulation, stability, and drug delivery systems. The combination of DVS and Raman spectroscopy reveals changes during ASA degradation, influenced by humidity and temperature. Analysing the process of dehydration of citric acid monohydrate is important when understanding drug release mechanisms. This has been shown to be affected by temperature and humidity, with higher humidity necessitating elevated temperatures to produce its anhydrous form. Understanding the changes and kinetics involved in these processes can influence decisions in pharmaceutical design, enhancing drug efficacy and shelf-life.

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The Pamas S40 GO

courtesy of Pamas

The Particle counter in a rugged case PAMAS GO for the remote on-site analysis of fluid samples – pressureless sampling and up to 420 bar system pressure testing

The rugged and resistant PAMAS S40 GO portable particle counter is built to meet the demands of the harshest environments and can be used for field analyses or laboratory measurements. The instrument includes an integrated battery for mains free operation on site. It is small and light enough to fit into an aircraft overhead locker. The rugged case PAMAS GO is watertight and protects the instrument against harsh environments and during transportation.

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EU GMP Annex 1 FAQs – Air Speed Strategies for Unidirectional Flows

courtesy of Particle Measuring Systems

The following frequently asked questions arose at a presentation given by PMS Senior GMP Scientist, Mark Hallworth, on the 6th of December on the topic of EU GMP Annex 1 Air Speed Strategies for Unidirectional Flows.


Why do manufacturers like ESCO, ThermoFisher Scientific, and Nuaire adopt different air speed values for 2A2 and 2B2 biological safety cabinets compared to the suggested range of 0.36 m/s to 0.54 m/s?

These manufacturers guarantee unidirectional airflow based on the speed ratings determined according to the specific equipment model. While the suggested range is 0.36 m/s to 0.54 m/s, the manufacturers may choose different values that they believe are optimal for their equipment.

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Applying Appropriate Limits in Cleanroom Monitoring

courtesy of Particle Measuring Systems

Selecting the right monitoring technique is pivotal in cleanroom contamination control. These specialized environments demand rigorous standards to ensure product integrity and safety. They are, after all, responsible for some of the most hygiene-critical applications on earth, from pharmaceutical manufacturing facilities to semiconductor fabrication plants.

 To minimize the risk of contamination and provide the highest cleanliness levels, stringent regulatory standards are implemented for cleanroom monitoring in sterile pharmaceutical manufacturing. These regulations help to provide more control over their environments. Examples of these standards include ISO 14644-1:2015 and the European Good Manufacturing Practice (EU GMP) Annex 1. 

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Surface measurement Systems introduces the IGC-SEA Nova

A bold new addition to the Inverse Gas Chromatography (iGC) line of Surface Energy Analyzers, the iGC-SEA Nova
combines all the unique capabilities of the original iGC-SEA instrument with a powerful new high-temperature sample oven.

 

 

 

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Start-up droptical and DataPhysics Instruments launch new dosing system

Flex Drop Dosing System FDDS XScourtesy of DataPhysics Instruments

DataPhysics Instruments and the start-up droptical from Nuremberg are bringing the FlexDrop dosing system to market. The FlexDrop dosing system is compatible with all contact angle meters of the OCA series and can dose tiny drops in the picolitre and nanolitre range. The two companies are thus setting new standards for contact angle and 1-click surface energy measurements, especially on very small surface areas.

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The PAMAS SBSS - the reference liquid particle counter

The PAMAS SBSS is the standard instrument used as a reference in many testing labs.

The instrument can be configured to measure a sample with the press of a single button. 

Actions like pre-filling sample, sample degassing with vacuum, and pressurising the sample
for a number of measurement runs are all done automatically.

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Contamination Control Strategies for Innovation and Regulatory Compliance FAQ

courtesy of Particle Measuring Systems

Maintaining environmental contamination control is one of the objectives of regulatory guidelines for the pharmaceutical field. As outlined in the EU GMP Annex 1 regulatory standard for sterile drug products, a Contamination Control Strategy (CCS) is a way to outline a method to identify and analyze risk, review the mitigating opportunities and innovations, and ultimately define corrective and preventive action plans. Implementation of a CCS attempts to address the varied causes of contamination and compromised sterility.

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The 2024 Carbon Capture Innovation Prize launches

courtesy of Surface Measurement Systems

Singapore, April 2024 | Surface Measurement Systems is thrilled to announce the launch of the 2024 Carbon Capture Innovation Prize, a prestigious competition designed to accelerate research in the field of carbon capture technology. In a groundbreaking initiative alongside MOF2024, this challenge aims to support researchers seeking to revolutionize the way we employ materials to combat carbon emissions via carbon capture, and to highlight their pioneering research work. The final winner of this Prize will be awarded a DVS Carbon instrument valued at over  $150,000, a state-of-the-art scientific instrument that accurately measures CO2 uptake in materials under a range of real-world conditions.

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Stability Analysis of Whey Based Beverages

courtesy of DataPhysics

Whey Based Beverages - Stability analysis of whey based beveragesWhey drinks area popular ready-to-drink protein beverages, owing to their excellent nutritional qualitiest and good flavor. To have a fresh and neutral taste, whey based beverages are usually prepared with fruits or vegetables. Stability issues are one of the major problems which are commonly encountered in this kind of beverages,
such as, crystallization of lactose stored in the fridge, coagulation of whey proteins amongst others. It is of great importance to study the stability of whey beverage formulations and modify them towards a better performance. With the MultiScan 20 (MS 20) (Fig. 2) dispersion stability analysis system from DataPhysics Instruments stability
changes can be detected and evalauted in a quantitative way much faster than any traditional shelflife test would permit. The stability study of four whey beverage formulations is presented throughout this application note.

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Introducing the Pamas S40 AVTUR

courtesy of Pamas

PAMAS S40 AVTURThe PAMAS S40 AVTUR is a portable particle counter for the analysis of turbine fuels and diesel. The S40 AVTUR has its own device-specific analysis method that is derived from the Energy Institute London standard IP 577. The S40 AVTUR instrument fully complies with DEFSTAN 91-091 and IP 630 (formerly IP PM FA). 

A wear-resistant ceramic piston pump guarantees a constant flow. The simple-to-use touchscreen user interface makes operation easy and intuitive. The system is equipped with an integrated battery for more than three hours of operation and data storage of more than 4000 measurements. The samples can be taken from bottles without pressure or pressurised up to 6 bar. Real-time sample measurement data can be printed during the analysis and previous results retrieved and re-printed if needed at any time at a later date.

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10 Years of BioCapt® Single Use Impactor

Microbial Data Collection environmental monitoring biocapt single use 10 yearscourtesy of Particle Measuring Systems

Particle Measuring Systems has recently announced 10 years of the Biocapt Single Use Microbial Impactor. This podcast specifically, covers the celebration of 10 years since its launch and its evolution and success, with a focus on its application in pharmaceutical production for microbial air sampling. 

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Measuring interfacial tension of insulating oil against water according to ASTM D971

courtesy of DataPhysics

Monitoring the degradation of insulating oil at an early stage is integral for detecting incipient faults within a transformer and avoiding catastrophic failures. The interfacial tension (IFT) is commonly considered to be an effective index for evaluating deterioration with increasing age, due to its high sensitivity to contaminants and impurities.

The ASTM D971 [1]Standard Test Method for Interfacial Tension of Insulating Liquids Against Water by the Ring Method is a widely used standard method to examine the quality of insulating oil. In the following, the application of the ASTM D971 will be presented using a tensiometer of the DCAT series  from DataPhysics Instruments.

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How to Choose the Right Cleanroom Particle Counter

courtesy of Particle Measuring Systems

Maintaining a contamination-free environment is a prerequisite for high-tech manufacturing and scientific research. Cleanrooms are central to this endeavour. Although a cleanroom is a critical part of maintaining a working environment, they cannot guarantee required cleanliness standards without robust monitoring systems such as particle counters and air quality monitors. A cleanroom particle counter directly contributes to air quality by measuring the concentration of airborne particles in the environment, which is essential for quality assurance (QA) and compliance. Here is a guide on how to choose the right particle counter for your cleanroom

 

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Sustainability at PAMAS

courtesy of Pamas

The moisture sorption capacity for building materials

courtesy of Surface Measurement Systems

The moisture sorption capacity for building materials such as cement, wood, insulation material, and fibers has significant implications
on a building’s lifespan, as well as having a big effect on indoor air quality and air-conditioning loads.

  

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How nature can inspire the development of new humidity and temperature controlled actuators

Actuatorcourtesy of DataPhysics Instruments

Pine cones only open when the weather is dry and warm; feather grass releases its seeds when the air humidity is high. Nature is full of environmentally adaptive materials
and has since inspired many man-made materials. In the field of building engineering, for example, temperature and humidity-dependent actuators are the key to
intelligent facades and roofs that can respond to changing weather conditions.

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5 Key Principles of Cleanroom Particle Counting

courtesy of Particle Measuring Systems 

Cleanroom particle counting is essential for accurate functioning and meeting certification criteria in controlled environments. In this blog post, we take a look at five key principles
of cleanroom particle counting, exploring the significance of each principle and how it contributes to maintaining the safety and quality of products manufactured in such environments.

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Are the results you report accurate? They are with PAMAS!

courtesy of Pamas

Understanding the phase separation behaviour of microemulsions for enhanced oil recovery processes

winsorcourtesy of DataPhysicis

Microemulsion mixtures are commonly used for enhanced oil recovery (EOR) processes due to their high crude oil extraction efficiency. Generally, such mixtures consist of a thermodynamically stable dispersion of crude oil, surfactant, and water or brine. The phase behaviour of the mixture changes from Winsor I to Winsor II by the way of Winsor III when adjusting temperature, salinity, and pressure. The Winsor III state is the most desirable during the EOR process. The dispersion stability analysis system MultiScan MS 20 from DataPhysics Instruments (Fig. 2) is a compact and versatile measuring device for the optical stability and aging analysis of a variety of multi-phase dispersions. The phase behaviour of a crude oil, surfactant, and water mixture will be presented in this application note

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Annex 1 2008 v. Annex 1 2022: A side-by-side comparison

fillingbcourtesy of Particle Measuring Systems

Annex 1 2008 is the basis for the 2022 version. This paper provides an easy-to-understand side-by-side comparison of the Annex 1 2008 v. 2022 versions, broken down by section.

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Using a Pamas particle counter for parts cleanliness

courtesy of Pamas

partsYou can measure the cleanliness of components and packing materials with an automatic particle counter. The surface cleanliness is analysed indirectly by
removing any particles from the surface through flushing, hosing, flooding or placing the item in an ultrasonic bath. The rinsing fluid is analysed with the liquid
particle counter. The surface contamination is calculated by comparing the results with a blank measurement of the clean rinsing fluid.

 

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Solubility

 courtesy of Surface Measurement Systems  

Solubility is a critical consideration across a wide range of industries. 
In pharmaceuticals, solubility is an incredibly important parameter needed to achieve the correct drug dosage in the body.
Poor solubility is often associated with higher doses needed to reach the correct bioavailability of the drug.
Solubility is affected by temperature, the solvent, and the properties of the compound undergoing dissolution.

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Finding a Particle Source via a Handheld Aerosol Particle Counter

courtesy of Particle Measuring Systems

Mini2Pinpointing a particle source can be a challenge in cleanrooms and laboratory flow equipment where the movement of clean air (which is the purpose of the air handling system) can mask particle generators such as faulty filters, motors, robots, operators and residual dust. 
The Handilaz® Mini II handheld particle counter has two significant advantages to help overcome this challenge.  First, the 0.2 micron sensitivity allows for measurement of particles that can affect the overall performance of rooms as clean as ISO Class 3.  Second, its small size allows the user to easily scan areas of interest without the weight, bulk and additional equipment required by other instruments. 

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Studying the stability and kinetics of fast-breaking foam

courtesy of DataPhysics Instruments

Cosmetics, detergents, and pharmaceuticals are often applied as foam due to its good spreading ability and its anti-stick properties. Many cosmetic manufacturers strive to develop foaming products, because consumers often consider foaming cleaning products as being of higher quality and providing better usability. Their stability has a significant influence on their applications. Foams consist of gas bubbles that are dispersed in a liquid phase. Because of various destabilisation mechanisms they are usually quite unstable.

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Sorption Science Bulletin Summer 2023

courtesy of Surface Measurment Systems

Staying up to date on the latest findings and insights is vital for researchers, allowing them to employ the best experimental practises and analytical techniques.

Below we have gathered all the relevant studie from 2023 so far to employ the DVS and iGC methods, providing key details on the use of sorption science instrumentation in a research setting.

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Drying and Dehydration

courtesy of Surface Measurment Systems

Matter under ambient conditions interacts with moisture and volatiles continuously. Exposure to heat and a high airflow over material will induce some form of drying. A material’s ability to resist rapid transitions between wet/hydrated states can be a good measure of stability.

Removal of volatiles from the surface of a solid can have a significant effect on the surface area by collapsing fragile crystals, altering surface energy, and changing the hydrated state of a solid. The degree of wetting and interaction with moisture can significantly change a material’s function and performance, therefore, monitoring its wettability/dry-ability is ever more necessary.

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Measuring the surface potential and isoelectric point of polyester fibres with a zeta potential analyzer

courtesy of DataPhysics

Fibres
Polyester fibres are synthetic fibres manufactured from polyethylene terephthalate. Polyester fibres are widely used in the textile industry. However, unmodified polyester fibres have deficiencies, e.g., a low water uptake, a hydrophobic character, and few reactive groups. This means they display a low affinity for dyes. Many techniques for improving the reactivity and hydrophilic character of polyester fibres exist in an industrial context. Generally, modifying fibres can enhance the interactions between the cations or anions of the dye and the functional groups on the fibre surface, and thus, the dyeability and water sorption of such fibres[1].

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Particle counter for aviation hydraulic fluids

courtesy of Pamas

Aviation hydraulic fluids The cleanliness control of hydraulic fluids is a typical application of optical particle counting with the aid of an Automatic Particle Counter. Hydraulic fluids are used for the transfer of energy in hydraulic systems. For smooth operation and uninterrupted maintenance of functionality, it is essential that the operating liquid is regularly controlled; a high degree of contamination could cause a malfunction within a component and may also lead to a complete system break-down. 

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EU GMP Annex 1 2022 FAQ's

courtesy of Particle Measuring Systems

Annex 1 is a regulation that outlines manufacturing requirements for sterile drugs made in and imported to the EU. In August 2022, a new revision of the EU GMP Annex 1 regulatory standard for sterile drug products was released, replacing the most recent draft from 2020 and the existing revision from 2008. Contamination control is vital in pharmaceutical manufacturing, and the requirements for environmental monitoring remain essentially the same in this revision; changes in the recent revision of Annex 1 highlight strategic control through further alignment with existing regulations from other organizations, the concept of a contamination control strategy (CCS), the separation and expanded guidance on Cleanroom Classification and Cleanroom Monitoring, and the definition of Quality Risk Management (QRM) as a central principle to defining processes, operations, and limits.

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DVS Carbon out now

We are happy to announce the release of the world’s first purpose-built gravimetric sorption analyzer for advanced CO2 capture, Utilization, and Storage (CCUS) applications.

With unique engineering and measurement capabilities, the DVS Carbon combined precise humidity control with dynamic mixing to enabled analaysis of CO2 uptake in materials in real-world conditions. 

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