Drying and Dehydration

courtesy of Surface Measurment Systems

Matter under ambient conditions interacts with moisture and volatiles continuously. Exposure to heat and a high airflow over material will induce some form of drying. A material’s ability to resist rapid transitions between wet/hydrated states can be a good measure of stability.

Removal of volatiles from the surface of a solid can have a significant effect on the surface area by collapsing fragile crystals, altering surface energy, and changing the hydrated state of a solid. The degree of wetting and interaction with moisture can significantly change a material’s function and performance, therefore, monitoring its wettability/dry-ability is ever more necessary.


The ultimate hydration state of a pharmaceutical material may influence several physicochemical properties including physical and chemical stability. For example, the hydration state of crystalline substances is of particular concern in the pharmaceutical industry. For instance, some hydrated materials become amorphous upon dehydration. Also, different hydrate forms can affect the material solubility, dissolution rate, flowability, and compressibility. These factors affect the entire chain of the drug development process from preformulation to solid form development to packaging and storage. Dynamic Vapor Sorption (DVS) allows the fast and accurate determination of channel hydrate formation and loss.


Application Note 59: Investigation of Channel Hydrate Formation and Loss Using the DVS | This email address is being protected from spambots. You need JavaScript enabled to view it.